Seconded, specifically what version of OsX are you on, and what version of Safari?
@blackorquidea do you happen to have any extensions installed in safari that might be interfering with audio playback?
Can you see if there are any errors in the javascript console? To open that, first enable the developer toolbar as per the instructions here: Use the developer tools in the Develop menu in Safari on Mac - Apple Support and then in the new Develop menu you’ll see open javascript console. Click that, try playing a sound from that settings page, and see if there’s any erorr message or anything like that, it might help illuminate what’s going on.